Publications

Mentzel, S., Martínez-Megías, C., Grung, M., Rico, A., Tollefsen, K.E., Van den Brink, P.J. and Moe, S.J. (2024). Using a Bayesian Network Model to Predict Risk of Pesticides on Aquatic Community Endpoints in a Rice Field—A Southern European Case Study. Environ. Toxicol. Chem. 43: 182-196. https://doi.org/10.1002/etc.5755

Welch, S.A., Olsen, K., Sharikabad, M.N., Tollefsen, K.E. Grung, M., Moe, J.S. (2023). Predicting Environmental Risks of Pharmaceuticals from Wholesales Data: An Example from Norway. Environ. Toxicol. Chem. 42: 2253-2270. https://doi.org/10.1002/etc.5702.

Hansen, B.H., Tarrant, A.M., Lenz, P.H. Roncalli, R., Almeda, R., Broch, O.J., Altin, A., Tollefsen, K.E. (2023). Effects of petrogenic pollutants on North Atlantic and Arctic Calanus copepods: From molecular mechanisms to population impacts. Aquatic Toxicol. 267: 106825. https://doi.org/10.1016/j.aquatox.2023.106825.

Song, Y., Zheng, K., Brede, D.A., Gomes, T., Xie, L., Kassaye, Y., Salbu, B., Tollefsen, K.E. (2023). Multiomics point of departure (moPOD) modeling supports an adverse outcome pathway network for ionizing radiation. Environ. Sci. Technol. 57:3198-3205. https://doi.org/10.1021/acs.est.2c04917

Chauhan, V. Yu, J., Vuong, N., Haber, L., Williams, A., Auerbach, S., Beaton, D., Wang, Y., Stainforth, R., Wilkins, R., Azzam, E.I., Richardson, R.B., Khan, G.M., Jadhav, A.; Burtt, J.J., Leblanc, J., Randhawa, K., Tollefsen, K.E., Yauk, C. (2023). Considerations for Application of Benchmark Dose Modeling in Radiation Research: Workshop Highlights. Int. J. Rad. Biol. 7: 1-12. https://doi.org/10.1080/09553002.2023.2181998.

Belfield, S.J., Enoch, S.J., Firman, J.W., Madden, J.C., Tollefsen, K.E. Cronin, M.T.D. (2023). A Review of Quantitative Structure-Activity Relationship Modelling Approaches to Predict the Toxicity of Mixtures. Comp. Toxicol. 25:100251. https://doi.org/10.1016/j.comtox.2022.100251

Tanabe S, Beaton D, Chauhan V, Choi I, Choi J, Clerbaux L-A, Coppola L, Dumont A, Esterhuizen M, Filipovska J, FitzGerald R, Fritsche E, Garcia-Reyero N, Goralczyk A, Huliganga E, Kim Y-J, Klose J, La Rocca C, Landesmann B, Mally A, Murugadoss S, Omeragic E, Ouédraogo G, Pereira J, Sadi B, Schaffert A, Song Y, Sovadinova I, Stöger T, Tollefsen KE, Wittwehr C, Yauk C (2023). Report of the 3rd and 4th Mystery of Reactive Oxygen Species Conference. ALTEX, 40: 689–693. https://doi.org/10.14573/altex.2307041.

Bajard, L., Adamovsky, O., Audouze, K., Baken, K., Barouki, R., Beltman, J.B., Beronius, A:, Bonefeld-Jørgensen, E.C., Cano-Sancho, G., de Baat, M.L., Di Tillio, F., Fernández, M.F., FitzGerald, R.E., Gundacker, C., Hernández, A.F., Hilscherova, K., Karakitsios, S., Kuchovska, E., Long, M., Luijten, M., Majid, S:, Marx-Stoelting, P., Mustieles, V., Negi, C.K., Sarigiannis, D., Scholtz, S:, Sovadinova, I., Stierum, R., Tanabe, S:, Tollefsen, K.E., van den Brand, A.D., Vogs, C., Wielsøe, M., Wittwehr, C., Blaha, L. (2023) Application of AOPs to assist regulatory assessment of chemical risks – case studies, needs, and recommendations. Environmental Research. 15:217:114650. https://doi.org/10.1016/j.envres.2022.114650.

Welch, S.A., Olsen, K., Sharikabad, M.N., Tollefsen, K.E. Grung, M., Moe, J.S. (2022). Pharmaceutical pollution: Prediction of environmental concentrations from national wholesales data. Open Research Europe. 2. https://api.semanticscholar.org/CorpusID:249292291.

Cao, Y., Moe, S.J., de Bin, R,. Tollefsen, K.E., Song, Y. (2022). A comparison of structural equation modeling and Bayesian network for de novo construction of a quantitative adverse outcome pathway network. ALTEX. ALTEX. 40: 287-298. https://doi.org/10.14573/altex.2207113.

Burtt, J., Leblanc, J., Randhawa, K., Ivanova, A:, Rudd, M., Wilkin, R., Azzam, E., Hecker, M., Horemans, N., Vanderhove, H., Adam-Guillermin, C., Armant, O., Klokov, D., Audouze, K., Kaiser, J.K., Moert, S., Lumniczky, K., Tanaka, I.B., Yutaka, Y., Hamada, N., Al-Nabulsi, I., Preston, J., Bouffler, S., Applegate, K., Cool, D., Beaton, D., Tollefsen, K.E. Garnier-Laplace, J., Laurier, D., Chauhan, V. (2022). Radiation Adverse Outcome Pathways (AOPs) are on the Horizon. Int. J. Rad. Biol. 98: 1763-1776. https://doi.org/10.1080/09553002.2022.2121439.

Xie, L., Song, Y., Petersen, K., Solhaug, K.A., Lind, O.C., Brede, D.A., Salbu, B., Tollefsen, K.E. (2022). Ultraviolet B modulates gamma radiation-induced stress responses in Lemna minor at multiple levels of biological organisation. Science of the Total Environment 846: 157457. https://doi.org/10.1016/j.scitotenv.2022.157457

Tollefsen, K. E., Alonzo, F., Beresford, N. A., Brede, D. A., Dufourcq-Sekatcheff, E., Gilbin, R., Horemans, N., Hurem, S., Laloi, P., Maremonti, E., Oughton, D., Simon, S., Song, Y., Wood, M. D., Xie, L., Frelon, S. (2022). Adverse outcome pathways (AOPs) for radiation-induced reproductive effects in environmental species: state of science and identification of a consensus AOP network. International Journal of Radiation Biology 17:1-34. https://doi.org/10.1080/09553002.2022.2110317

Beyer, J., Tveiten, L.; Song, Y., Tollefsen, K.E., Berge, J.A., Helland, A., Øxnevad, S., Schøyen, M. (2022). A review of the ecotoxicology of marine tributyltin (TBT) hotspots: A review. Marine Environmental Research 179: 105689. https://doi.org/10.1016/j.marenvres.2022.105689

Tanabe, S., O'Brien, J., Tollefsen, K.E., Kim, Y-J., Chauhan, V., Yauk, C., Huliganga, E., Rudel, R.A., Kay, J.E., Helm, J.S., Beaton, D., Filipovska, J., Sovadinova, I., Garcia-Reyero, N., Mally, A:, Poulsen, S.A., Delrue, N., Fritsche, E., Luettich, K., La Rocca, C., Yepiskoposyan, H., Klose, J., Høgh Danielsen, P., Esterhuizen, M., Jacobsen, N.R., Vogel, U., Gant, T.W., Choi, I., FitzGerald, R. (2022). Reactive Oxygen Species in the Adverse Outcome Pathway framework: towards Creation of Harmonized Consensus Key Events. Frontiers in Toxicology 4: 887135. https://doi.org/10.3389/ftox.2022.887135

Mentzel, S. , Grung, M. , Holten, R. , Tollefsen, K.E., Stenrød, M., Moe, S.J. (2022). Probabilistic risk assessment of pesticides under future agricultural and climate scenarios using a bayesian network. Frontiers in Environmental Science 10: 957926. https://doi.org/10.3389/fenvs.2022.957926

Mentzel, S. , Grung, M. , Tollefsen, K.E., Stenrød, M., Petersen, K., Moe, S.J. (2021). Development of a Bayesian network for probabilistic risk assessment of pesticides. Integrated Environmental Assessment and Management 18: 1072-1087. https://doi.org/10.1002/ieam.4533

Leblanc, B.J., Randhawa, K., Ivanova, A., Rudd, M., Wilkin, R., Wilkin, R., Azzam, E., Hecker, M., Horemans, N., Vanderhove, H., Adam-Guillermin, H., Armant, C., Klokov, O., Audouze, K., Kaiser, J.K.,Moert, S., Lunickzky, K., Tanaka, I.B., Yutaka, Y., Hamada, N., Al-Nabulsi, I., Preston, J., Bouffler, S., Applegate, K., Cool, D., Beaton, D., Tollefsen, K.E., Garnier-Laplace, J., Laurier, D., Chauhan, V. (2022). Radiation adverse outcome pathways (AOPs) are on the horizon: Advancing radiation protection through international Horizon-style exercise. International Journal of Radiation Biology 17. https://doi.org/10.1080/09553002.2022.2121439

Chauhan, V., Hamada, N., Wilkins, R., Garnier-Laplace, J., Laurier, D., Beaton, D., Tollefsen, K.E. (2022). A high-level overview of the organisation for economic co-operation and development of an Adverse Outcome Pathway Programme. International Journal of Radiation Biology 17. https://doi.org/10.1080/09553002.2022.2110311

Tollefsen, K. E., Alonzo, F., Beresford, N. A., Brede, D. A., Dufourcq-Sekatcheff, E., Gilbin, R., Horemans, N., Hurem, S., Laloi, P., Maremonti, E., Oughton, D., Simon, S., Song, Y., Wood, M. D., Xie, L., & Frelon, S. (2022). Adverse outcome pathways (AOPs) for radiation-induced reproductive effects in environmental species: state of science and identification of a consensus AOP network. International Journal of Radiation Biology 17: https://doi.org:10.1080/09553002.2022.2110317

Jaylet, T., Quintens, R., Benotmane, M. A., Luukkonen, J., Tanaka, I., Ibanez, C., Durand, C., Sachana, M., Azimzadeh, O., Adam-Guillermin, C., Tollefsen, K. E., Laurent, O., Audouze, K., & Armant, O. (2022). Development of an Adverse Outcome Pathway for radiation induced microcephaly via expert consultation and machine learning. International Journal of Radiation Biology 17: https://doi.org:10.1080/09553002.2022.2110312

Chauhan, V., Hamada, N., Garnier-Laplace, J., Laurier, D., Beaton, D., Tollefsen, K. E., & Locke, P. A. (2022). Establishing a Communication and Engagement Strategy to Facilitate the Adoption of the Adverse Outcome Pathways in Radiation Research and Regulation. International Journal of Radiation Biology 17. https://doi.org:10.1080/09553002.2022.2086716

Xie, L., Macken, A., Johnsen, B., Norli, M., Skogan, O.A.S., Tollefsen, K.E. (2022). The MicroClimate Screen – A microscale climate exposure system for assessing the effect of CO2, temperature and UV on marine microalgae. Marine Environmental Research 179:105670. https://doi.org/10.1016/j.marenvres.2022.105670

Chauhan, V., Beaton, D., Hamada, N., Wilkins, R., Burtt, J., Leblanc, J., Cool, D., Garnier-Laplace, J., Laurier, D., Le, Y., Yamada, Y., Tollefsen, K.E. (2022). Adverse Outcome Pathway: A Path towards better Data Consolidation and Global Co-ordination of Radiation Research. International Journal of Radiation Biology 7: 1-10. https://doi.org/10.1080/09553002.2021.2020363

Toyota, K., Watanabe, H., Hirano, M., Abe, R., Miyakawa, H., Song, Y., Sato, T., Miyagawa, S., Tollefsen, K.E., Yamamoto, H., Tatarazako, N., Iguchi, T. (2022). Juvenile hormone synthesis and signaling disruption triggering male offspring induction and population decline in cladocerans (water flea): Review and adverse outcome pathway development. Aquatic Toxicology 243: 106058. https://doi.org/10.1016/j.aquatox.2021.106058

Grung, M., Meland, S., Ruus, A., Ranneklev, S., Fjeld, E., Kringstad, A., Rundberget, J.T., Cruz, Majbrit D., Christensen, J.H. (2021). Occurrence and trophic transport of organic compounds in sedimentation ponds for road runoff. Science of the Total Environment 751: 141808. https://doi.org/10.1016/j.scitotenv.2020.141808

Kjær, C., Sørensen, P.B., Wiberg-Larsen, P., Bak, J., Bruus, M., Strandberg, B., Larsen, S.E. Rasmussen, J.J., Strandberg, M. (2021). Vulnerability of Aquatic Insect Species to Insecticides, Depending on Their Flight Period and Adult Life Span. Environmental Toxicology and Chemistry 40: 1778-1787. https://doi.org/10.1002/etc.5025

Lerebours, A., Murzina, S., Song, Y., Tollefsen, K.E., Benedetti, M., Regoli, F., Rotchell, J.M., Nahrgang, J. (2021). Susceptibility of polar cod (Boreogadus saida) to a model carcinogen. Marine Environmental Research 170: 105434. https://doi.org/10.1016/j.marenvres.2021.105434

Moe, S.J.., Carriger, J.F., Glendell, M. (2021). Increased Use of Bayesian Network Models Has Improved Environmental Risk Assessments. Integrated Environmental Assessment and Management 17: 53-61. https://doi.org/10.1002/ieam.4369

Moe, S.J., Wolf, R., Xie, L., Landis, W.G., Kotamäki, N., Tollefsen, K.E. (2021). Quantification of an Adverse Outcome Pathway network by Bayesian regression and Bayesian network modelling. Integrated Environmental Assessment and Management 17: 147-164. https://doi.org/10.1002/ieam.4348

Scheibener, S., Song, Y., Tollefsen, K.E., Salbu, B., Teien, H.C. (2021). Uranium accumulation and toxicokinetics in the crustacean Daphnia magna provide perspective to toxicodynamic responses. Aquatic Toxicology 235: 105836. https://doi.org/10.1016/j.aquatox.2021.105836

Schmid, S., Song, Y., Tollefsen, K.E. (2021). AOP report: Inhibition of Chitin Synthase 1 leading to Increased Mortality in Arthropods. Environmental Toxicology and Chemistry. Pathways and predictions. 40: 2112–2120. https://doi.org/10.1002/etc.5058

Song, Y., Kamstra, J.H., Cao, Y., Asselman, J., Anglès d'Auriac, M., Friberg, N. (2021). High-throughput analyses and Bayesian network modeling highlight novel epigenetic Adverse Outcome Pathway networks of DNA methyltransferase inhibitor mediated transgenerational effects. Journal of Hazardous Materials 408: 124490. https://doi.org/10.1016/j.jhazmat.2020.124490

Song, Y., Villenueve, D.L. (2021). AOP Report: Uncoupling of Oxidative Phosphorylation Leading to Growth Inhibition via Decreased Cell Proliferation. Environmental Toxicology and Chemistry 40: 2959-2967. https://doi.org/10.1002/etc.5197

Steindal, E. H., Grung, M. (2021). Management of PFAS with the aid of chemical product registries—an indispensable tool for future control of hazardous substances. Integrated Environmental Assessment and Management 17: 835-851. https://doi.org/10.1002/ieam.4380

Wiberg-Larsen, P., Nørum, U., Rasmussen, J.J. (2021). Repeated insecticide pulses increase harmful effects on stream macroinvertebrate biodiversity and function. Environmental Pollution 273: 116404. https://doi.org/10.1016/j.envpol.2020.116404

Wolf, R., Tollefsen, K.E. (2021). A Bayesian approach to incorporating spatiotemporal variation and uncertainty limits into modeling of predicted environmental concentrations from chemical monitoring campaigns. Environmental Science and Technology 55: 1699-1709. https://dx.doi.org/10.1021/acs.est.0c06268?ref=pdf

Xie, L., Solhaug, K.A., Song, Y., Johnsen, B, Tollefsen, K.E. (2020). Effects of artificial ultraviolet B radiation on the macrophyte Lemna minor: a conceptual study for toxicity pathway characterization. Planta. 252: 86. doi.org/10.1007/s00425-020-03482-3

Song, Y., Xie, L., Lee, Y.K., Tollefsen, K.E. (2020). De novo Development of a Quantitative Adverse Outcome Pathway (qAOP) Network for Ultraviolet B (UVB) Radiation Using Targeted Laboratory Tests and Automated Data Mining. Environ. Sci. Technol. 54(20): 13147-13156. doi.org/10.1021/acs.est.0c03794.

Thaulow, J., Song, Y., Lindeman, L.C., Kamstra, J.H., Lee, Y., Xie, L., Aleström, P., Salbu, B., Tollefsen, K.E. (2020) Epigenetic, transcriptional and phenotypic responses in Daphnia magna exposed to low-level ionizing radiation. Environmental Research. 190: 109930. doi.org/10.1016/j.envres.2020.109930

Mellor, C.L., Tollefsen, K.E., Lalone, C., Cronin, M.T.D. and Firman, J.W. (2020). In silico identification of chemicals capable of binding to the ecdysone receptor. Environ. Toxciol.Chem. 39 (7): 1438-1450. doi.org/10.1002/etc.4733

Song, Y., Xi, L., Lee, Y. Brede, D.A., Lyne, F., Kassaye, Y., Thaulow, J., Caldwell, G., Salbu, B., Tollefsen, K.E. (2020). Integrative assessment of low-dose gamma radiation effects on Daphnia magna reproduction: Toxicity pathway assembly and AOP development. Science of the Total Environment 705: 135912. doi.org/10.1016/j.scitotenv.2019.135912

Moe, S.J., Hjermann, D.Ø., Ravagnan, E., Bechmann, R.B. (2019). Effects of an aquaculture pesticide (diflubenzuron) on non-target shrimp populations: extrapolation from laboratory experiments to the risk of population decline. Ecological Modelling. 413: 108833. doi.org/10.1016/j.ecolmodel.2019.108833

Schirmer, K., Stadnicka, J., Belanger, S. Blaha, L., Bols, N., Dyer, S: Embry, M., Fischer, M., Halder, M., Hermens, J., Hultman, M.T., Kramer, N., Laue, H., Lee, L., Lillicrap, A, Natsch, A. Segner, H., Tanneberger, K., Tollefsen, K.E., Werner, I., Witters, H., and Zupanic, A. (2019). Cell-based data to predict the toxicity of chemicals to fish. Commentary on the manuscript by Rodrigues et al., 2019. Cell-based assays seem not to accurately predict fish short-term toxicity of pesticides. Environmental Pollution 252:476-482. doi.org/10.1016/j.envpol.2019.113060

Faust, M., Backhaus, T., Altenburger, R., Dulio, V., van Gils, J., Ginebreda, A., Kortenkamp, A:, Munthe, J., Posthuma, L., Slobodnik, J., Tollefsen, K.E., van Wezel, A. amd Brack, W. (2019). Prioritisation of water pollutants. The EU Project SOLUTIONS proposes a methodological framework for the integration of mixture risk assessments into prioritisation procedures under the European Water Framework Directive. Environ Sci Eur. 31: 66-70. doi.org/10.1186/s12302-019-0239-4

Lindeman, L.C., Thaulow, J., Song, Y., Kamstra, J.H., Xie, Li., Asselman, J., Aleström, P., Tollefsen, K.E. (2019). Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-Azacytidine. Environmental Epigenetics. 5.(3) s.dvz016. doi.org/10.1093/eep/dvz016

Blagojevic, D., Lee, Y.K., Xie, L., Brede, D.A., Nybakken, L., Lind, O.C., Tollefsen, K.E., Salbu, B., Solhaug, K.A., Olsen, J.E. (2019). No Evidence of a Protective or Cumulative Negative Effect of UV-B on Growth Inhibition Induced by Gamma Radiation in Scots Pine (Pinus Sylvestris) Seedlings. Photochemical & Photobiological Sciences. 18(8), 1945-1962. doi.org/10.1039/C8PP00491A

Evenseth, L.M., Kristiansen, K., Song, Y., Tollefsen, K.E. Sylte, I. (2019) In silico site-directed mutagenesis of the Daphnia magna ecdysone receptor identifies critical amino acids for species-specific and inter-species differences in agonist binding. Comp. Toxicol. 12: 100091. doi.org/10.1016/j.comtox.2019.100091

Xie, L., Solhaug, K.A., Brede, D.A. Lind, O.C., Song, Y. Salbu, B., Tollefsen, K.E. (2019). Modes of action and adverse effects of gamma radiation in the aquatic macrophytes Lemna minor. Sci. Total. Environ. 680:23-34. doi.org/10.1016/j.scitotenv.2019.05.016

Salbu, B., Lind, O.C., Teien, H.C., Tollefsen, K.E. (2019). Why is the multiple stressor concept of relevance to radioecology? Int J. Rad Biol. 11:1-10. doi.org/10.1080/09553002.2019.1605463

Almeida, A.C., Gomes, T., Langford, K., Thomas, K.V., Tollefsen, K.E. (2019). Oxidative stress potential of the herbicides bifenox and metribuzin in the microalgae Chlamydomonas reinhardtii. Aquatic Toxicology. 210:117-128. doi.org/10.1016/j.aquatox.2019.02.021

Fischer, M., Belanger, S., Berckmans, P., Bernhard, M., Blaha, L.., Coman Schmid, D., Dyer, S., Haupt, T., Hermens, J., Hultman, M. T., Laue, H.; Lillicrap, A., Mlnaříková, M., Natsch, A., Novák, J.; Sinnige, T.; Tollefsen, K.E. von Niederhäusern, V., W, H., Zupanic, A., Schirmer, K. (2019). Repeatability and reproducibility of the RTgill-W1 cell line assay for predicting fish acute toxicity. Tox. Sci. 169: 353-364. doi.org/10.1093/toxsci/kfz057

Song, Y., Nahrgang, J., Tollefsen, K.E. (2019). Transcriptomic analysis reveals dose-dependent toxic mechanisms of benzo(a)pyrene in polar cod (Boreogadus saida). Sci. Total. Environ. 653:176-189. doi.org/10.1016/j.scitotenv.2018.10.261

Hultman M.T, Løken K.B., Grung, M., Reid M. and Lillicrap A. (2019). Performance of 3D hepatic spheroids in a biotransformation study of Pyrene. Environmental Chemistry and Toxicology. 38(8):1738-1747. doi.org/10.1002/etc.4476

Moe, S.J., Hjermann, D.Ø., Ravagnan, E., Bechmann, R.B. (accepted). Effects of an aquaculture pesticide (diflubenzuron) on non-target shrimp populations: extrapolation from laboratory experiments to the risk of population decline. Ecological Modelling. 413. doi.org/10.1016/j.ecolmodel.2019.108833

Hevrøy, T. H., Golz, A. L., Xie, L., Hansen, E. L., & Bradshaw, C.,2019. Radiation effects and ecological processes in a freshwater microcosm. Journal of environmental radioactivity. 203: 71-83. doi.org/10.1016/j.jenvrad.2019.03.002

Myklebust E.B., Jimenez-Ruiz E., Chen J., Wolf R., Tollefsen, K.E., 2019. Knowledge Graph Embedding for Ecotoxicological Effect Prediction. Int’l Sem. Web Conf. (ISWC), LNCS 11779 doi.org/10.1007/978-3-030-30796-7_30

Myklebust, E.B., Jimenez-Ruiz, E., Chen, J., Wolf, R., Tollefsen, K.E. (2019) Knowledge graph embedding for ecotoxicological effect prediction. CEUR Workshop Proceedings 2019 ; Volume 2456.(10) s. 37-40 arxiv.org/abs/1907.01328

Lindeman, L.C. Thaulow, J., Song, Y. Kamstra, J.H., Xie, L. Asselman, J., Aleström, P., Tollefsen, K.E. (2019). Epigenetic, transcriptional and phenotypic responses in two generations of Daphnia magna exposed to the DNA methylation inhibitor 5-Azacytidine. Environmental Epigenetics 2019. 5.(3) s.dvz016. doi.org/10.1093/eep/dvz016

Tousova, S., Froment, J., Oswald, P., Thomas, K.V., Tollefsen, K.E., Reid, M., Langford, K., Slobodník, J., Hilscherova, K., Blaha, L. (2018) Identification of algal growth inhibitors in treated wastewater using effect-directed analysis based on non-target screening techniques. J. of Maz. Mat., 358: 494-502. doi.org/10.1016/j.jhazmat.2018.05.031

Hiruta, C., Kakui, K., Tollefsen, K.E., Iguchi,T (2018). Targeted gene disruption by use of CRISPR/Cas9 ribonucleoprotein complexes in the water flea Daphnia pulex. Genes to Cells. 23:494-502. doi.org/10.1111/gtc.12589

Altenburger, R., Escher, B., Jakobs, G., Krauss, M., Krüger, J., Neale, P., Ait-Aissa, S., Almeida, A.C., Seiler, T.B., Brion, F., Hilscherova, K., Hollert, H., Novak, J., Schlichting, R., Serra, H., Peng, Y., Tindall, A., Tollefsen, K.E., Umbuzeiro, G., Williams, T., Kortenkamp, A., Scholze, M. (2018). Mixture effect detection in complex contaminated samples – an interlaboratory comparative study using effect-based methods. Environment International. 114: 95-106. doi.org/10.1016/j.envint.2018.02.013

Song, Y., Asselman, J., De Schamphelaere, K.A.C., Salbu, B., Tollefsen, K.E. (2018). Deciphering the Combined Effects of Environmental Stressors on Gene Transcription: a Conceptual Approach. Environ. Sci. Technol. 52: 5479-5489. doi.org/10.1021/acs.est.8b00749

Gomes, T., Song, Y., Brede, D.A., Xie, L., Gutkzow, K.B., Salbu, B., Tollefsen, K.E. (2018). Gamma radiation induces dose-dependent oxidative stress and transcriptional alterations in the freshwater crustacean Daphnia magna. Sci. Total Environ. 628-629: 206-216. doi: 10.1016/j.scitotenv.2018.02.039.

Xie, L., Gomes, T., Solhaug, K.A., Song, Y., Tollefsen, K.E. (2018). Linking mode of action of the model respiratory and photosynthesis uncoupler 3,5-dichlorophenol to adverse outcomes in Lemna minor. Aquatic Toxicology. 197: 98-108. doi.org/10.1016/j.aquatox.2018.02.005

Miyakawaa, H., Song, Y., Tollefsen, K.E., Iguchi, T. (2017). Ecdysteroid and juvenile hormone biosynthesis, receptors and their signaling in the freshwater microcrustacean Daphnia. J Steroid Biochem Mol Biol. pii: S0960-0760(17), 30370-30379 doi.org/10.1016/j.jsbmb.2017.12.006

Bridges, J., Sauer, U.G., Buesen, R., Deferme, L., Tollefsen, K.E., Tralau, T., van Ravenzwaay, B., Poole, A., Pemberton, M. (2017). Framework for the quantitative weight-of-evidence analysis of ‘omics data for regulatory purposes. Regul. Toxicol. Pharmacol. 91: S46-S60. doi.org/10.1016/j.yrtph.2017.10.010

Gant, T.W., Sauer, U.G., Zhang, S.D., Chorley, B.N., Hackermüller, J., Perdichizzi, S., Tollefsen, K.E., van Ravenzwaay, B., Yauk, C., Tong, W., Poole, A. (2017). A generic Transcriptomics Reporting Framework (TRF) for ‘Omics Data Processing and Analysis. Regul. Toxicol Pharmacol. 91: S36-S45 doi.org/10.1016/j.yrtph.2017.10.010

Kauffmann, H.M., Fuchs, R., Chorley, B.N., Deferme, L., Ebbels, T., Hackermüller, J., Perdichizzi, S. Poole, A. Sauer, U.G., Tollefsen, K.E., Tralau, T., Yauk, C., van Ravenzwaay, B. (2017). Framework for the quality assurance of ’omics technologies considering GLP requirements. Regul Toxicol Pharmacol. 91: S27-S36 doi.org/10.1016/j.yrtph.2017.10.007

Buesen, R., Chorley, B.N., da Silva Lima, B., Daston, G., Deferme, L., Ebbels, T., Gant. T.W., Goetz, A., Greally, J., Gribaldo, L., Hackermüller, J., Hubesch, B., Jennen, D., Johnson, K., Kanno, J., Kauffmann, H.M., Laffont, M. Meehan, R., Pemberton, M., Perdichizzi1, S., Piersma, A.H., Sauer, U.G., Schmidt, K., Seitz, H., Sumida, K., Tollefsen, K.E., Tong, W., Tralau, T., van Ravenzwaay, B., Weber, R., Worth, A., Yauk, C., Poole, A. (2017). Applying ‘omics technologies in chemicals risk assessment: Report of an ECETOC workshop. Regul Toxicol Pharmacol. 91: S3-S13 doi.org/10.1016/j.yrtph.2017.09.002

Tollefsen, K.E. and Kacew, S. (2017). 6th Norwegian Environmental Toxicology symposium: Assessing and solving environmental challenges in a multiple stressor world. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 805-806. doi.org/10.1080/15287394.2017.1352159

Almeida, A.C., Petersen, K., Langford, K., Thomas, K.V. and Tollefsen, K.E. (2017). Toxicity of biocides on the growth and PSII efficiency of Chlamydomonas reinhardtii. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 971-986. doi.org/10.1080/15287394.2017.1352176

Hultman, M.T., Petersen, K., Tollefsen, K.E. (2017). Characterizing combined effects of antiestrogenic chemicals on vitellogenin production in rainbow trout (Oncorhynchus mykiss) hepatocytes. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 987-1001. doi.org/10.1080/15287394.2017.1354435

Petersen, K., Hultman, M.T., Bytingsvik, J., Harju, M., Evenset, A., Tollefsen, K.E. (2017). Characterizing cytotoxic and estrogenic activity of Arctic char tissue extracts in primary Arctic char hepatocytes. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 1017-1030. doi.org/10.1080/15287394.2017.1357277

Song, Y., Evenseth, L.M., Iguchi, T., Knut Erik Tollefsen (2017). Release of chitobiase as an indicator of potential molting disruption in juvenile Daphnia magna exposed to ecdysone receptor agonists Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 954-962. doi.org/10.1080/15287394.2017.1352215

Tollefsen, K.E., Song, Y., Høgåsen, T., Øverjordet, I.B., Altin, D., Hansen, B.H. (2017). Acute and sublethal toxicity of mercury to the marine copepod Calanus finmarchicus. Journal of Toxicology and Environmental Health, Part A. 80 (16-18): 845-861. doi.org/10.1080/15287394.2017.1352198

Petersen, K., Hultman, M.T., Rowland, S., Tollefsen, K.E. (2017). Toxicity of organic compounds from unresolved complex mixtures (UCMs) to primary fish hepatocytes. Aquatic Toxicology. 190:150-161. doi.org/10.1016/j.aquatox.2017.06.007

Tousova, Z, Oswald, P., Slobodnik, J., Muz, M., Hu, H., Brack, W., Krauss, M., Koprivica, S., Ahel, M., Schollee, J., Hidasi, A., Hollender, J., Schirmer, K-, Suter, M.J.F., Sonavane, M., Ait-Aissa, S:, Creusot, N., Brion, F., Di Paolo, C., Seiler, T.B., Hollert, H., Froment, J., Almeida, A.C., Thomas, K.V., Tollefsen, K.E., m Tufi, S., Ouyang, X., Leonards, P., Lamoree, M., Torrens, V.O., Schriks, M., Kolkman, A.M., Spirhanzlova, P., Tindall, A., Blaha, L., Schulze, T. (2017). EDA-EMERGE – European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants with adverse effect potential in European surface waters. Sci. Total. Environ. 601-602: 1849-1868. doi.org/10.1016/j.scitotenv.2017.06.032

Almeida, A.C., Gomes, T. Langford, K., Thomas, K.V., Tollefsen, K.E. (2017). Oxidative stress in the algae Chlamydomonas reinhardtii exposed to biocides. Aquatic Toxicology. 189: 50-59. doi.org/10.1016/j.aquatox.2017.05.014

Brockmeier, E., Hodges, G., Hutchinson, T.H., Butler, E., Hecker, M., Tollefsen, K.E., Garcia-Reyero, N., Kille, P., Becker, D., Chipman, K., Colbourne, J., Collette, T., Cossins, A., Cronin , M., Graystock, P., Gutsell, S., Knapen, D., Katsiadaki, I., Lange, A., Marshall, S. Owen, S., Perkins, E.J., Plaistow, S., Schroeder, A:, Taylor, D., Viant, M., Ankley, G., Falciani, F. (2017). The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment. Toxicological Sciences. 158 (2): 252-262. doi.org/10.1093/toxsci/kfx097

Neale, P. A., Altenburger, R., Ait-Aissa, S., Brion, F., Busch, W., de Aragao Umbuzeiro, G., Denison, M. S., Du Pasquier, D. Hilscherova, K., Hollert, H., Morales, D. A. Novak, J. ., Schlichting, R. . Seiler, T. B., Serra, H., Shao, Y., Tindall, A. J., Tollefsen, K. E. Williams, T. D. and B. I. Escher (2017). Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water, Water Res, 123: 734-50. doi.org/10.1016/j.watres.2017.07.016

Fay, K.A., Villeneuve, D.L., Lalone, C.A. Song, Y., Tollefsen, K.E., Ankley, G.T. (2017). Practical approaches to adverse outcome pathway (AOP) development and weight of evidence evaluation as illustrated by ecological case studies. Environ. Toxicol. Chem. 36(6):1429-1449. doi.org/10.1002/etc.3770

Song, Y., Villeneuve, D.; Toyota, K.; Iguchi, T., Tollefsen, K.E. (2017). Ecdysone Receptor Agonism Leading to Lethal Molting Disruption in Arthropods: Review and Adverse Outcome Pathway Development. Environ. Sci. Technol., Critical reviews. 51 (8): 4142–4157 doi.org/10.1021/acs.est.7b00480

Petersen, K., Hultman, M., Tollefsen, K.E. (2017). Primary hepatocytes from Arctic char (Salvelinus alpinus) as an environmentally relevant Arctic in vitro model for screening contaminants and environmental extracts. Aquatic toxicology. 187: 141–152. doi.org/10.1016/j.aquatox.2017.03.023

Schulze, T., Ahel, M., Ahlheim, J., Aït-Aïssa, S., Brion, F., Di Paolo, C., Froment, J., Hidasi, A.O., Hollender, J., Hollert, H., Hu, M., Kloß, A., Koprivica, S., Krauss, M., Muz, M., Petre, M., Oswald, P., Schollée; J.E. Seiler, T.B., Shao, Y., Slobodnik, J., Sonavane, M., Suter, M., Tousova, Z., Tollefsen, K.E., Walz, K.H., Brack, W. (2017). Assessment of a novel device for onsite integrative large-volume solid phase extraction of water samples to enable a comprehensive chemical and effect-based analysis. Sci. Total Environment. 581-582: 350–358. doi.org/10.1016/j.scitotenv.2016.12.140

Ouyang, X., Froment, J., Leonards, P. E.G., Christiensen, G., Tollefsen, K.E., de Boer, J., Thomas, K.V., Lamoree, M.H. (2017). Miniaturization of a transthyretin binding assay using a fluorescent probe for high throughput screening of thyroid hormone disruption in environmental samples. Chemosphere. 171: 722–728. doi.org/10.1016/j.chemosphere.2016.12.119

Gomes, T., Xie, L., Brede, D., Lind, O.C., Solhaug, K.A., Salbu, B., Tollefsen, K.E. (2017). Sensitivity of the green algae Chlamydomonas reinhardtii to ionizing (gamma) radiation: photosynthetic performance and ROS formation. Aquatic Toxicology. 183:1-10. doi.org/10.1016/j.aquatox.2016.12.001