Factors influencing activities of biotransformation enzymes, concnetrations and compositional patterns of organochlorines in members of a marine food web

Academic article

Year of publication: 2002
Journal: Aquatic Toxicology
External websites: Cristin
Involved from NIVA: Anders Ruus
Contributors: Anders Ruus, Morten Sandvik, Karl Ugland, Janneche Utne Skaare

Summary

The accumulation of PCB, DDT, chlordanes, hexachlorocyclohexanes, hexachlorobenzene and mirex was studied in a marine food chain consisting of bullrout, cod, herring gull and harbor seals. Furthermore hepatic biotransformation enzyme activities (ethoxyresorufin-O-deethylase (EROD), penoxyresorufin-O-depentylase (PROD) and glutathion S-transferase (GST)) were measured in all species. High correlations between EROD and PROD activities were found in all species, suggesting a single common catalyst CYP1A. GST activities were dependent on biological factors: age in harbor seals and sex in bullrouts.